Is interferons a regulatory protein?

Is interferons a regulatory protein?

Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression).

What do interferon regulatory factors do?

Interferon regulatory factors (IRFs) are a family of transcription factors that regulate many aspects of innate and adaptive immune responses—including driving anti-viral responses, responding to pathogens to drive pro-inflammatory responses and regulating immune cell differentiation (1).

What does IRF4 gene do?

IRF4 was identified as a key factor with essential functions in lymphocytes, where it directs the development, affinity maturation, and terminal differentiation of B cells and has critical roles in diverse effector T cells.

Is IRF4 a transcription factor?

Immune cell development. IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors.

What is interferon in English?

Interferons (IFNs, /ˌɪntərˈfɪərɒn/) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.

Is irf7 an ISG?

While IRF-3 is constitutively expressed in many tissues, IRF-7 is an ISG required for the expression of most IFN-α subtypes, and thus a key mediator of the type I IFN amplification loop [2], [9], [10].

What is the regulatory factor of childbirth?

Oxytocin is a hormone that acts on organs in the body (including the breast and uterus) and as a chemical messenger in the brain, controlling key aspects of the reproductive system, including childbirth and lactation, and aspects of human behaviour.

How is interferon activated?

Type I-IFN expression is induced by activation of PRRs and by cytokines (9, 16). While, several different cell types express IFN-β, IFN-α is secreted only by hematopoietic cells, predominately plasmacytoid dendritic cells (17).