What data and tools does UniProt provide?

To build upon this protein data and to aid analysis, UniProt provides three main tools; ‘BLAST’ (Basic Local Alignment Search Tool), ‘Align’ multiple sequence alignment tool and ‘Retrieve/ID Mapping’ for batch retrievals of UniProt entries and ID mapping between UniProt and external databases.

Is Swiss-Prot and UniProt same?

UniProtKB/TrEMBL is a computer-annotated (unreviewed) supplement to Swiss-Prot, which strives to gather all protein sequences that are not yet represented in Swiss-Prot.

How reliable is UniProt?

UniProtKB encompasses several individual protein sequence resources that are depicted on this page. If you are talking about a sequence that is from SwissProt (manually reviewed/curated sequences) or UniRef100 clusters then that sequence is likely perfectly accurate.

What is the difference between Swiss-Prot and TrEMBL?

TrEMBL consists of entries in a SWISS-PROT format that are derived from the translation of all coding sequences in the EMBL nucleotide sequence database, that are not in SWISS-PROT. Unlike SWISS-PROT entries those in TrEMBL are awaiting manual annotation.

What kind of database is UniProt?

The UniProt Knowledgebase (UniProtKB) is an expertly curated database, a central access point for integrated protein information with cross-references to multiple sources. The UniProt Archive (UniParc) is a comprehensive sequence repository, reflecting the history of all protein sequences (1).

Is UniProt a database?

The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), and the UniProt Archive (UniParc).

Can you cite UniProt?

https://www.uniprot.org/uniparc/UPI00000002E4. Remarks: A UniProtKB accession number (AC) is a stable identifier and therefore allows unambiguous citation of a UniProtKB entry.

Why is UniProt important?

UniProt is the central resource for storing and interconnecting information from large and disparate sources, and the most comprehensive catalog of protein sequence and functional annotation.

How do I access Swiss-Prot?

There are multiple sites on the Web that can access the Swiss-Prot/TrEMBL and retrieve the database. Its main sites are the ExPASy Molecular Biology website (http://www.expasy.org/) and the European Institute of Bioinformatics (EBI) website (http://www.ebi.ac.uk/swissprot/).

What does Swiss-Prot entry contain?

SWISS-PROT contains the information about the name and origin of the protein, protein attributes, general information, ontologies, sequence annotation, amino acid sequence, bibliographic references, cross-references with sequence, structure and interaction databases, and entry information.

What is the use of UniProt?

Is UniProt a primary database?

Uniprot was originally formulated as a primary database for protein sequences and functional annotation based on experimental evidence. Nowadays it combines a network of sister databases centralising all levels of annotation produced for protein sequences.

How can I map UniProt IDs to RefSeq transcripts?

UniProt provides mapping tables so you can figure out what RefSeq transcripts these proteins correspond to. Under downloads > ID mapping data (see readme ). The full mapping files are huge (~2GB) but I only want human, so HUMAN_9606_idmapping.dat.gz will do. Will get you a two-column lookup table matching the UniProt ids to RefSeq transcripts:

How do deletions happen in UniProt?

The UniProt FAQ on deletions says most deletions happen when the putative protein-coding sequence in the relevant DNA reference is deleted, or when someone realizes that an open reading frame doesn’t actually encode a protein like they thought it did.

What is the Uniprot ID of a protein?

Each protein is identified by its UniProt id, such as B4DFA2. To be precise, these are UniProtKB AC ids, distinct from UniProtKB ID ids.