How is AmBisome administered?

AmBisome should be administered by intravenous infusion over a 30 – 60 minute period. For doses greater than 5mg/kg/day, intravenous infusion over a 2 hour period is recommended (see section 4.4). The recommended concentration for intravenous infusion is 0.20 mg/ml to 2.00 mg/ml amphotericin B as AmBisome.

What should be administered before amphotericin B?

Administering 500–1000 mL bolus of normal saline before and after amphotericin B infusion can reduce the incidence and severity of nephrotoxicity. (8) Fevers, chills, and rigors are also minimized by providing acetaminophen, diphenhydramine, and/or hydrocortisone 30–60 minutes prior to amphotericin B administration.

How do you prescribe amphotericin B?

Amphotericin B injection comes as a solid powder cake to be made into a solution and then injected intravenously (into a vein) by a nurse or a doctor. Amphotericin B injection is usually infused (injected slowly) intravenously over a period of 2 to 6 hours once daily.

What are contraindications for amphotericin B?

systemic mastocytosis. low amount of magnesium in the blood. low amount of potassium in the blood. decreased kidney function.

Can AmBisome be given peripherally?

In high-resource settings, intravenous (IV) administration of amphotericin B deoxycholate is typically given through a central line. However, in resource-limited settings, amphotericin is typically administered via peripheral venous access due to limited supplies.

How do you administer amphotericin?

General

1. Amphotericin B should be administered intravenously under close clinical observation by medically trained personnel.
2. Rapid intravenous infusion has been associated with hypotension, hypokalemia, arrhythmias, and shock and should, therefore, be avoided (see DOSAGE AND ADMINISTRATION).

What is the most common drug used to treat oral candidiasis?

Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and …

What is the major side effect of amphotericin B?

The principal acute toxicity of AmB deoxycholate includes nausea, vomiting, rigors, fever, hypertension or hypotension, and hypoxia. Its principal chronic adverse effect is nephrotoxicity. AmB probably produces renal injury by a variety of mechanisms.

What is the most common adverse reaction to amphotericin B?

The most common side effects of amphotericin B include: Loss of potassium. Loss of magnesium. Anaphylaxis.

What is AmBisome used for?

This medication is used to treat a variety of serious fungal infections. It is often used in patients who cannot tolerate or who do not respond to the regular amphotericin treatment. It works by stopping the growth of fungi.

How do I prescribe AmBisome®?

2. 1 The physician wishing to prescribe AmBisome® for an adult patient will contact pager #3333 between the hours of 0700 and 2200 to reach the ID fellow or attending ID physician on call. If ID approval is given, the ordering physician will then inform the unit pharmacist that approval has been given.

How many units of AmBisome are in a 50MG vial?

AMBISOME® Liposomal amphotericin B 50 mg Powder for dispersion for infusion. PRESENTATION: Sterile, powder for dispersion for infusion. Each vial contains 50mg of amphotericin B (50,000 units), encapsulated in liposomes.

Is AmBisome safe to use with amphotericin B?

AmBisome – contains less than 1 mmol sodium (23 mg) per vial. INTERACTIONS: No interaction studies have been performed with AmBisome, however some medicinal products known to interact with amphotericin B may interact with AmBisome. See SmPC for full list. REGNANCY/LACTATION: Safety not established, the risk/benefit assessmentshouldbe considered.

What is the sodium content of AmBisome?

AmBisome – contains less than 1 mmol sodium (23 mg) per vial. INTERACTIONS: No interaction studies have been performed with AmBisome, however some medicinal products known to interact with amphotericin B may interact with AmBisome. See SmPC for full list.