What is EPOR gene?

The EPOR gene provides instructions for making a protein called the erythropoietin receptor. Erythropoietin is a hormone that directs the production of new red blood cells (erythrocytes) in the bone marrow.

What is the gene code for erythropoietin?

EPO Gene – Erythropoietin The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading …

Where is the erythropoietin receptor?

erythroid progenitor cells
In the erythropoietic process, EPO induces homodimerization of the EPO receptor, which is located on the surface of erythroid progenitor cells.

What is the most potent stimulus for erythropoietin production?

Hypoxia is the most potent stimulus to the production of erythropoietin by the kidneys. In the healthy individual, erythropoietin exerts its effects in the bone marrow to help in the production of RBCs, thereby improving oxygen concentration in the blood, relieving the hypoxia.

What is EPO injection?

Descriptions. Epoetin injection is a man-made version of human erythropoietin (EPO). EPO is produced naturally in the body, mostly by the kidneys. It stimulates the bone marrow to produce red blood cells. If the body does not produce enough EPO, severe anemia can occur.

How many amino acids are in erythropoietin?

165 amino acids
Erythropoietin (EPO) is a 30,400 daltons glycoprotein, consisting of 165 amino acids produced mainly in the kidney and in the liver and regulating erythrocyitosis. It primarily acts on erythroid precursor cell at colony-forming units-erythroid stage inhibiting the apoptosis.

Does bone marrow produce erythropoietin?

What is erythropoietin? Red blood cells are produced in the bone marrow (the spongy tissue inside the bone). In order to make red blood cells, the body maintains an adequate supply of erythropoietin (EPO), a hormone that is produced by the kidney. EPO helps make red blood cells.

Is EpoR a GPCR?

EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers….Erythropoietin receptor.

What are the benefits of erythropoietin?

In order to make red blood cells, the body maintains an adequate supply of erythropoietin (EPO), a hormone that is produced by the kidney. EPO helps make red blood cells. Having more red blood cells raises your hemoglobin levels.

What happens if you have too much erythropoietin?

What happens if I have too much erythropoietin? Excess erythropoietin results from chronic exposure to low oxygen levels or from rare tumours that produce high levels of erythropoietin. It causes a condition known as polycythaemia which means high red blood cell count.

Is EPO illegal?

EPO is prohibited at all times under the WADA Prohibited List and is the most commonly used non-Specified Substance in the class of Peptide Hormones, Growth Factors, and Related Substances in category S2.

What does the EPOR gene do?

Learn more The EPOR gene provides instructions for making a protein called the erythropoietin receptor. Erythropoietin is a hormone that directs the production of new red blood cells (erythrocytes) in the bone marrow.

What does EpoR mean?

EPOR (Erythropoietin Receptor) is a Protein Coding gene. Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia . Among its related pathways are ERK Signaling and CREB Pathway .

What is the erythropoietin receptor gene?

Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] EPOR (Erythropoietin Receptor) is a Protein Coding gene. Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia . Among its related pathways are ERK Signaling and CREB Pathway .

How many EpoR mutations cause erythrocytosis?

At least 16 mutations in the EPOR gene have been found to cause familial erythrocytosis, an inherited condition characterized by an increased number of red blood cells and an elevated risk of abnormal blood clots. When familial erythrocytosis results from EPOR gene mutations, it is often designated ECYT1.

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