What does TGF b1 do?

Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.

What does it mean if TGF-beta 1 is high?

While having a normal level of human transforming growth factor-beta 1 indicates a healthy immune system, high levels of this growth factor can indicate several diseases and conditions like, chronic inflammatory response syndrome, cancer, tumor cells, fibrosis, and many more.

What is the difference between TGF-beta 1 and 2?

TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems.

How does TGF-beta work?

At late stages of tumor progression, TGF-beta promotes tumorigenesis via suppression of the immune system and changes in cell differentiation of epithelial tumor cells, a phenomenon termed epithelial to mesenchymal transdifferentiation (EMT). We review our work on the role of the Smad pathway in controlling EMT.

What is the function of the protein encoded by the TGF-beta gene?

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase.

What is the function of TGFβ-1?

The TGFβ-1 protein triggers chemical signals that regulate various cell activities inside the cell, including the growth and division (proliferation) of cells, the maturation of cells to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis).

What does TGFB1 stand for?

The TGFB1 gene provides instructions for producing a protein called transforming growth factor beta-1 (TGFβ-1).

Is TGF-beta1 associated with benign and malignant breast tumors?

several polymorphisms detected in the TGFbeta1 gene and its receptor associated with benign and malignant breast tumors Following TGF-beta1 treatment, the activity of serine/threonine phosphatase and recruitment of PP2A-Balpha by TbetaRI increased in benign cells, but not in malignant cells.