What is ERG in biology?

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of transcription factors with roles in development that include vasculogenesis, angiogenesis, haematopoiesis and bone development. ERG’s oncogenic potential is well known because of its involvement in Ewing’s sarcoma and leukaemia.

What is NGFI A?

Definition. NGFI-A. Nerve Growth Factor Inducible A Gene.

Is ERG a proto oncogene?

Cancer. This gene can be classified as a proto-oncogene.

What is ERG overexpression?

INTRODUCTION. ERG overexpression resulting from the rearrangement between the TMPRSS2 promoter and the coding regions of the ERG gene has been identified as the most common alteration in prostate cancer (PrCa), accounting for more than 90% of the TMPRSS2-ETS family rearrangements [1–3].

How is an ERG performed?

During an ERG recording session, the patient looks into a bowl displaying different amounts of light. Retinal cells emit small electrical signals when stimulated by certain types of light. The ERG machine records the resulting electric signals’ amplitude (voltage) and time course.

What does ERG positive mean?

Positive staining – normal. Both blood vessel and lymphatic endothelial cells. Subpopulation of immature myeloid cells in an adult bone marrow. Early embryonic subepidermal and paraspinal mesenchyme and periphery of cartilage (Am J Surg Pathol 2011;35:432)

What is TMPRSS2 ERG?

TMPRSS2 is a prostate-specific and androgen-response gene that encodes a protein belonging to the serine protease family, which functions in prostate carcinogenesis and relies on gene fusion with ETS transcription factors, such as ERG and ETV1 (8).

What drugs are endocrine therapy?

4. Hormone therapy drugs

• Tamoxifen.
• Aromatase inhibitors (letrozole, anastrozole and exemestane)
• Goserelin (Zoladex)
• Leuprorelin (Prostap)
• Fulvestrant (Faslodex)

What is an erg in biology?

An erg is approximately the amount of work done (or energy consumed) by one common house fly performing one “push up”, the leg-bending dip that brings its mouth to the surface on which it stands and back up. 1 erg = 10 −7 J = 100 nJ; 1 erg = 10 −10 sn⋅m = 100 psn⋅m = 100 picosthène-metres; 1 erg = 624.15 GeV = 6.2415 × 10 11 eV

What is the Emergency Response Guidebook (ERG)?

PHMSA’s 2016 Emergency Response Guidebook provides first responders with a go-to manual to help deal with hazmat transportation accidents during the critical first 30 minutes. DOT’s goal is to place an ERG in every public emergency service vehicle nationwide.

How do you calculate erg in physics?

1 erg = 10−7 J = 100 nJ. 1 erg = 10−10 sn⋅m = 100 psn⋅m = 100 pico sthène -metres. 1 erg = 624.15 GeV = 6.2415 × 1011 eV. 1 erg = 1 dyn ⋅cm = 1 g⋅cm2/s2.

What is transcriptional regulator ERG?

Transcriptional regulator ERG is a protein encoded by ERG (ETS family transcription factor ERG), which is located at 21q22 Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity