What does CYP24A1 do?

CYP24A1 is an enzyme expressed in the mitochondrion of humans and other species. It catalyzes hydroxylation reactions which lead to the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D.

What is CYP24A1 gene?

The CYP24A1 gene provides instructions for making an enzyme called 24-hydroxylase. This enzyme helps control the amount of active vitamin D available in the body.

Where is 24-hydroxylase?

24-Hydroxylase, encoded by the CYP24A1 gene, is the key enzyme which converts 1,25(OH)2D3 to less active calcitroic acid. Nearly all cell types express 24-hydroxylase, the highest activity being observed in the kidney.

What is CYP24?

CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer. Int J Cancer.

Does cholecalciferol increase calcium?

Nevertheless, cholecalciferol may increase serum calcium, and there seems to be an additive effect when patients simultaneously use calcium supplements. This case underscores the need for physicians to be attentive to the possibility of hypercalcemia in patients treated with both high-dose cholecalciferol and calcium.

Is cholecalciferol a calcium?

Descriptions. Cholecalciferol is a dietary supplement that is used to treat vitamin D deficiency. It is also used with calcium to maintain bone strength. This medicine is available both over-the-counter (OTC) and with your doctor’s prescription.

Can low vitamin D levels cause hypercalcemia?

Vitamin D deficiency can cause mild hypercalcemia but can also mask underlying primary hyperparathyroidism—as it did in this case. A Tc-99 sestamibi parathyroid scan will often localize a parathyroid adenoma.

Should you take calcium supplements if you have hypercalcemia?

Tell your doctor about any family history of hyperparathyroidism, kidney stones, or high blood calcium. This can help them monitor and catch your hypercalcemia early. Avoid taking calcium-rich supplements or antacids without consulting your doctor first.