Where is PAX7 located?

PAX7 is expressed in the palatal shelf of the maxilla, Meckel’s cartilage, mesencephalon, nasal cavity, nasal epithelium, nasal capsule and pons. Pax7 is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. It can bind to DNA as an heterodimer with PAX3.

Where is the PAX3 gene located?

The human PAX3 gene is located in the 2q36. 1 chromosomal region, and contains 10 exons within a 100 kb region.

What does PAX1 gene do?

PAX1 is essential for development and function of the human thymus. Temporal and spatial expression of Sox9, Pax1, TGF-beta1 and type I and II collagen in human intervertebral disc development. Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer.

What is Pax7 a marker for?

Discussion. The transcription factor PAX7 is an established marker for satellite cells in adult skeletal muscle.

What are Pax7 positive cells?

Cell transplantation and lineage-tracing studies have demonstrated that Pax7-expressing (Pax7(+)) satellite cells can repair damaged muscle tissue repeatedly after several bouts of acute injury. These findings provided evidence that Pax7(+) cells are muscle stem cells.

What are Pax7 satellite cells?

In adult muscle, satellite cells express Pax7, a paired-box transcription factor, and remain quiescent under normal physiological conditions.

What type of gene is PAX3?

PAX3 Gene – Paired Box 3 This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development.

What chromosome is the PAX3 gene on?

PAX3 is the chromosome 2 locus rearranged by the 2;13 translocation (Figure 1; Barr et al., 1993). This gene encodes a member of the paired box transcription factor family and is expressed in skeletal muscle progenitors.

What protein does PAX1 produce?

Paired box protein Pax-1 is a protein that in humans is encoded by the PAX1 gene….

What organisms have PAX1 gene?

Homologs of the PAX1 gene: The PAX1 gene is conserved in Rhesus monkey, dog, cow, mouse, chicken, zebrafish, and frog.

Do myoblasts express Pax7?

Therefore, maintained expression of Pax7 in satellite-cell-derived myoblasts is compatible with differentiation and fusion into multinucleated myotubes. Maintained Pax7 expression delays the onset of myogenin expression.

What is the PAX7 gene?

PAX7 (Paired Box 7) is a Protein Coding gene. Diseases associated with PAX7 include Myopathy, Congenital, Progressive, With Scoliosis and Rhabdomyosarcoma 2 . Among its related pathways are Mesenchymal Stem Cells and Lineage-specific Markers and Neural Crest Differentiation .

What is the function of the paired box 7 gene?

The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

What is the function of the PAX3 gene?

The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

What is Pax7 expression in rhabdomyosarcoma?

PAX7 expression is a useful marker of skeletal muscle differentiation in rhabdomyosarcoma, particularly of the embryonal subtype, with specificity for rhabdomyosarcoma and Ewing sarcoma.

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