What medications should not be taken with milk thistle?

Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes:

• Allergy drugs.
• Drugs for high cholesterol.
• Anti-anxiety drugs.
• Antiplatelet and anticoagulant drugs (blood thinners).
• Some cancer drugs.
• Drugs broken down by the liver.

Does milk thistle interact with other drugs?

Possible interactions include: Cytochrome P450 2C9 (CYP2C9) substrates. Taking milk thistle might affect this enzyme and drugs it processes, such as diazepam (Valium), warfarin (Jantoven) and others. This means milk thistle might affect the levels of these drugs in your body.

Is milk thistle a CYP3A4 inhibitor?

In vitro, milk thistle has been shown to inhibit the activity of CYP3A4 [44,45]; however, in vivo studies have shown the effects of milk thistle on the pharmacokinetics of PIs to be negligible.

How is milk thistle metabolized?

In conclusion, after oral administration of standardized milk thistle extracts, silymarin flavonolignans, the major biologically active components in milk thistle, are rapidly metabolized and measurable in plasma, mainly in the form of glucuronides.

Can I take milk thistle with high blood pressure medication?

If you take any medicines regularly, talk to your doctor before you start using milk thistle. It could interact with many drugs, including some that treat high cholesterol, infections, insomnia, and blood pressure.

Can you take milk thistle with high blood pressure medication?

Does milk thistle interact with Xanax?

Possible Interactions with: Milk Thistle Drugs for high cholesterol — such as lovastatin (Mevacor, Altocor) Anti-anxiety drugs — including alprazolam (Xanax), diazepam (Valium), and lorazepam (Ativan) Antiplatelet and anticoagulant drugs (blood thinners) — including clopidogrel (Plavix) and warfarin (Coumadin)

What are the actions of milk thistle?

Mechanisms of Action Evidence exists that milk thistle may be hepatoprotective through a number of mechanisms: antioxidant activity, toxin blockade at the membrane level, enhanced protein synthesis, antifibriotic activity, and possible anti-inflammatory or immunomodulating effects.

What is Lagosa used for?

It normalizes and stabilizes the action of liver cells. Lagosa is in the form of coated tablets intended for oral use. indications: Conditions after liver damage caused by toxic compounds; as an adjunct treatment in chronic liver inflammation.

Does milk thistle interact with blood pressure medication?

Can you take milk thistle while on antidepressants?

Interactions between your drugs No interactions were found between milk thistle and Zoloft.

Does milk thistle inhibit cytochrome P450 3A4?

Cytochrome P450 3A4 substrates: Milk thistle inhibits cytochrome P450 3A4 and can affect the intracellular concentration of drugs metabolized by this enzyme. However, conflicting data indicate no such effects . In another study, consumption of milk thistle did not reduce levels of indinavir, an AIDS drug .

Does milk thistle increase risk of raloxifene exposure?

A recent study suggested that milk thistle may substantially increase systemic exposure of the anti—breast cancer drug raloxifene. 1 Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme.

Does milk thistle cause drug interactions?

Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Drs. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy.

Does milk thistle have any effect on P-gp?

Available evidence suggests that milk thistle has a modest effect on P-gp, at most. More study is needed to confirm this. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1. 5