What is the histiocyte?

A histiocyte is a type of immune cell. It destroys foreign substances to protect the body from infection.

What is the difference between macrophage and histiocyte?

Histiocyte and dendritic cell lineages DCs, monocytes, and macrophages are members of the mononuclear phagocyte system,2 whereas a histiocyte is a morphological term referring to tissue-resident macrophages. Macrophages are large ovoid cells mainly involved in the clearance of apoptotic cells, debris, and pathogens.

What is a histiocyte macrophage?

A histiocyte is a less phagocytic form of a macrophage with fewer lysosomal granules. Histiocytes may form clusters, or even fuse together into mulitnucleated giant cells. These giant cells are particularly evident on bone marrow biopsy from a patient with a marrow granuloma.

What is the origin of histiocytes?

Histiocytes are derived from the bone marrow by multiplication from a stem cell. The derived cells migrate from the bone marrow to the blood as monocytes.

How do you identify histiocytes?

In smears, the typical histiocyte is easily identified by its size, eccentric round or bean-shaped nucleus, and lightly stained lacy cytoplasm (Fig. 19.43). Because histiocytes are phagocytic, their cytoplasm may contain leukocytes, nuclear particles (Fig.

What are macrophages derived from?

Macrophages originate from blood monocytes that leave the circulation to differentiate in different tissues. There is a substantial heterogeneity among each macrophage population, which most probably reflects the required level of specialisation within the environment of any given tissue.

Are histiocytes white blood cells?

Histiocyte cells are a form of white blood cells that help the immune system destroy foreign materials and fight infection. The extra immune cells produced by this condition may form tumors, which can affect parts of the body like the bones and possibly spread to other areas.

What is histiocytes?

Histiocytes are also known as reticuloendothelial cells and reticulum cells. A macrophage that does not migrate. A macrophage in connective tissue. Want to thank TFD for its existence?

What are histiocytes and Langerhans cells?

Histiocytes differentiate from CD34+ stem cell precursors into macrophages and several DC lineages, which encompass Langerhans cells (LCs) and interstitial DCs. Langerhans cells occur within epithelia of the skin, alimentary, respiratory and reproductive tracts.

What is the difference between histiocytes and dendritic cells?

Histiocyte is now considered an overarching term to describe cells of dendritic cell (DC) or macrophage lineage. Histiocytes differentiate from CD34+ stem cell precursors into macrophages and several DC lineages, which encompass Langerhans cells (LCs) and interstitial DCs.

What are histiocytes in congestive heart failure?

Histiocytes (pleural fluid, congestive heart failure). A, Like mesothelial cells, histiocytes are usually dispersed as isolated cells, but centrifugation for cell block sections compresses them into large groups. Compare the histiocytes, which have an oval or folded nucleus, to the mesothelial cell (arrow).