What is nitroglycerin used for?

Nitroglycerin is used to prevent angina (chest pain) caused by coronary artery disease. This medicine is also used to relieve an angina attack that is already occurring.

What is the action of NTG?

The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds.

Is NTG a beta blocker?

Nitrates: nitroglycerin, isosorbide dinitrate. Beta Blockers: propranolol, metoprolol, atenolol. Calcium Channel Blockers: nifedipine, verapamil, diltiazem.

Is nitroglycerin used for anxiety?

Stress is invariably diminished by purposeful activity. Being able to terminate an anginal episode promptly, or better still to prevent its occurrence, puts one in control. Taking nitroglycerin is a self-empowering act. Being in control ameliorates fear and anxiety.

Which drugs are prodrugs?

Examples of prodrugs that exist naturally or were produced unintentionally during drug development include aspirin, psilocybin, parathion, irinotecan, codeine, heroin, L-dopa, and various antiviral nucleosides.

Is NTG a vasodilator?

NTG is a peripheral and coronary vasodilator. NTG reduces preload via venous dilation, and achieves modest afterload reduction via arterial dilation. These effects result in decreased myocardial oxygen demand. In addition, NTG induces coronary vasodilation, thereby increasing oxygen delivery.

What drug worsens angina?

Worsening of angina – Beta blockers can promote arterial spasm, meaning they cause the walls of the arteries to spasm and narrow, so they may actually worsen angina in people with variant angina (angina caused by spasm).

Does nitroglycerin relieve chest pain?

Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring.

How many prodrugs are there?

Approximately 10% of all marketed drugs worldwide can be considered prodrugs. Since 2008, at least 30 prodrugs have been approved by the FDA.

What is difference between drug and prodrug?

Drugs can be metabolized by several tissues and organs, such as the kidneys, lungs and intestines, but the main site of metabolism is the liver, which is rich in enzymes. A prodrug is a medication that the body converts into a pharmacologically active drug after it is administered.

Can NTG cause bradycardia?

Abstract. Nitroglycerin (NTG) may cause paradoxical bradycardia and occasional life-threatening hypotension.