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What causes high C4A complement levels?

Answer: Possible causes of elevated complement levels include: cancer, viral infections, non-alcoholic fatty liver disease, metabolic syndrome, obesity, diabetes, heart disease, autoimmunity (psoriasis, ulcerative colitis).

What causes high C4A complement levels?

Answer: Possible causes of elevated complement levels include: cancer, viral infections, non-alcoholic fatty liver disease, metabolic syndrome, obesity, diabetes, heart disease, autoimmunity (psoriasis, ulcerative colitis).

What is C4A in complement?

C4a, which is an anaphylatoxin, activates inflammatory immune cells, whereas C4b binds to C1, resulting in the formation of a protease that cleaves C2 into C2a and C2b.

What is a normal C4A?

Optimal Result: 0 – 650 ng/mL. The complement C4 test is one of the most frequently used complement component tests. Your doctor may order a complement C4 test if you’re experiencing symptoms that indicate an autoimmune disease.

What does C4A level test for?

A complement C4 (also known as a complement component 4, or simply C4) is a test to measure the level of C4 proteins you have in your blood. These proteins play a role in how your immune system functions and defends your body from harmful bacteria and viruses.

What is the function of C4A?

The absence of a C4a receptor, coupled with the inability to bind and signal effectively through the C3aR and C5aR, suggests that the primary function of C4a is to serve as the ‘pro’ portion of C4, stabilizing C4 and its thioester bond until the classical or lectin pathways are activated.

What is chronic inflammatory response syndrome?

Chronic Inflammatory Response Syndrome (CIRS) is a progressive, multi-system, multi-symptom illness characterized by exposure to biotoxins. The ongoing inflammation can affect virtually any organ system of the body and if left untreated becomes debilitating.

What do high levels of C3 and C4 mean?

It seems that elevated C3 and C4 are likely to result of increased synthesis in the liver in response to cytokines e.g. IL-1β, IL-6 or tumor necrosis factor (TNF), which are increased in active CU and are known to control synthesis of the APR proteins [9].

What is a C3 and C4 blood test for?

C3 & C4 Blood Test measures the levels of Complement component 3 and Complement component 4 in the blood. The complement system comprises of more than 30 proteins in the blood, that play a significant role in the body’s immune system.

What is a C4A blood test?

What is C4A gene?

C4A (Complement C4A (Rodgers Blood Group)) is a Protein Coding gene. Diseases associated with C4A include Complement Component 4A Deficiency and Blood Group, Chido/Rodgers System. Among its related pathways are Immune response Lectin induced complement pathway and Innate Immune System.

What is considered a high C4A level?

According to SurvivingMold.com, C4a raised levels can mean a person is hypersensitive and should not live in a home with an ERMI score above 2. C4A levels may be decreased with mycotoxin avoidance. Mold can grow inside homes, schools, and workplaces undetected for years and fueled by damp conditions.

What does a high C4A level mean?

C4A appears to be an immune marker (has increased levels) in the following disorders: Lupus [ 11] and higher C3a [ 6 ]…According to one study, lower C4a contributes to lupus [ 12 ]. It’s been observed that C4A levels can be increased in people with Lyme disease [ 5 ].

What is C3a and C4A?

C4A is an activation protein, which means it also activates the other complement proteins to increase in level [ 1 ]. The C3a, C4a, and C5a components are referred to as anaphylatoxins, causing smooth muscle contraction, histamine release from mast cells, and enhanced vessel permeability [ 2 , 3 ].

What is a good complement C4A level?

Complement C4a Optimal Result: 0 – 650 ng/mL. The complement C4 test is one of the most frequently used complement component tests. Your doctor may order a complement C4 test if you’re experiencing symptoms that indicate an autoimmune disease.

Can a doctor check your C4A level?

C4A Test You can request that your doctor test your C4A. Conventional doctors will look at high or low C4A levels and not mention anything. Sometimes, a lab result may be in the reference range, but not actually be in the optimal range.