Is carvedilol better than metoprolol?

Based on the results of the COMET trial, the authors concluded that carvedilol, at a dose of 25 mg twice daily, provides superior morbidity and mortality benefit compared to metoprolol tartrate at a dose of 50 mg twice daily.

How does carvedilol differ from metoprolol?

Metoprolol primarily works on the receptors in the heart, but carvedilol works on both of types of receptors—and as it turns out, that’s important for heart failure.

Does metoprolol affect glucose levels?

Metoprolol increased the blood glucose concentrations during the first 10 min of an i.v. glucose tolerance test (IVGTT) as compared with placebo (p less than 0.02) and propranolol (p less than 0.05).

Does carvedilol increase blood sugar?

Low blood sugar (hypoglycemia)—May worsen low blood sugar (hypoglycemia) levels caused by insulin and may delay recovery of blood sugar levels; in patients with diabetes and heart failure, carvedilol may further increase blood sugar levels; in addition, if your diabetes medicine causes your blood sugar to be too low.

What is a good replacement for carvedilol?

The best replacement for carvedilol will depend on the condition being treated. There are only two medications FDA-approved to treat heart failure other than carvedilol: bisoprolol and metoprolol succinate. Other examples of beta-blockers include atenolol, nebivolol, and propranolol.

Can I switch from carvedilol to metoprolol?

Thus, when switching the beta-blocker from carvedilol to metoprolol, the initial metoprolol dose should not exceed 50 mg per 25 mg of carvedilol with consecutive uptitration to the maximum tolerated dose, while a change from metoprolol to carvedilol is well tolerated with 25 mg carvedilol per 100 mg of metoprolol.

Is carvedilol better than metoprolol for CHF?

Conclusions: Both metoprolol and carvedilol were equally effective in improving symptoms, quality of life, exercise capacity and LV ejection fraction, although carvedilol lowers blood pressure more than metoprolol.

What is a good substitute for carvedilol?

Does metoprolol affect insulin?

Metoprolol is a β1 receptor-selective antagonist widely used to prevent cardiovascular disease. Like non-selective beta blockers, metoprolol has been reported to increase fasting glucose concentrations and/or insulin concentrations and to decrease insulin sensitivity as measured by HOMA-IR.

Does diltiazem impair glucose metabolism?

(2) The administration of diltiazem or enalapril did not have any influence on HbA1c levels. These findings suggest that not only beta-blocker but nicardipine (dihydropyridine type calcium-channel blocker) may cause deterioration in glucose metabolism in NIDDM patients.

Does metoprolol cause insulin resistance?

Does carvedilol strengthen the heart?

However, it is known that carvedilol improves the workload of your heart, exercise-induced high heart rate, and high heart rate upon standing. It also widens your blood vessels, which helps to decrease your blood pressure.

What are the differences between carvedilol and metoprolol?

Carvedilol and metoprolol tartrate are beta-adrenergic blocking agents ( beta-blockers) used to treat high blood pressure ( hypertension) and congestive heart failure.

Does carvedilol lower blood pressure more than metoprolol?

However, because metoprolol may not work as well as carvedilol in terms of reducing blood pressure—and metoprolol seems to also raise blood sugar—carvedilol might be better here. Carvedilol seems to be better at preventing cardiovascular events (like heart attacks) in people with high blood pressure.

Is carvedilol superior to metoprolol in heart failure?

While carvedilol appears to be preferable to metoprolol tartrate for patients with heart failure, there is currently no evidence to demonstrate that it is superior to higher doses of metoprolol tartrate (e.g. 200 mg per day) or metoprolol succinate.

Is it advised to prescribe both sotolol and carvedilol?

Carvedilol (Coreg) can have negative interaction with Certain arrhythmia medications. It belongs to class of drugs called beta blockers. It can have negative interaction with these arrhythmia medications drugs–Propafenone (Rythmol)-Quinidine-Sotalol (Betapace) It is advised not to take Carvedilol and Sotalol together.