How do you replace surfactant therapy?

Medical practitioner or NNP to administer the surfactant via the pre-cut tube to the distal end of the endotracheal tube in a single bolus dose or in two aliquots as quickly as the neonate tolerates. The total dose is usually given less than a minute.

Is there artificial surfactant?

Abstract. Artificial surfactant (ALEC), when used in a crystalline state, has physical properties similar to natural surfactant. It is composed of two phospholipids with no protein. When placed in the trachea of ventilated premature rabbits it significantly increased the lung compliance.

What is exogenous surfactant made of?

Surfactant is composed of ∼80–85% phospholipids, 5–10% neutral lipids and 8–10% protein, with 5–6% consisting of the four specific surfactant proteins.

What is artificial surfactant called?

Lucinactant is the first U.S. FDA-approved protein-containing synthetic surfactant. It was approved by the U.S. FDA in March 2012 as the fifth surfactant to treat neonatal RDS following colfosceril palmitate (Exosurf), beractant (Survanta), calfactant (Infasurf), and poractant alfa (Curosurf).

What is a potential complication with surfactant replacement?

The short-term risks of surfactant replacement therapy include bradycardia and hypoxemia during instillation, as well as blockage of the endotracheal tube (36).

How do you give SURVANTA?

Recommended Dosage Four doses of SURVANTA can be administered in the first 48 hours of life. Doses should be given no more frequently than every 6 hours. The need for additional doses of SURVANTA is determined by evidence of continuing respiratory distress.

What is artificial surfactant made of?

Synthetic pulmonary surfactants: Colfosceril palmitate (Exosurf) – a mixture of DPPC with hexadecanol and tyloxapol added as spreading agents. Pumactant (Artificial Lung Expanding Compound or ALEC) – a mixture of DPPC and PG.

Where does artificial surfactant come from?

Once physicians diagnose an infant with respiratory distress syndrome, they can treat the infant by administering artificial surfactant. In the US, artificial surfactant used for surfactant replacement therapy is extracted from the lung of a cow or a pig.

Can you give adults surfactant?

Administration of exogenous pulmonary surfactant is an adjunctive therapy that may help adult patients with ARDS. Pulmonary surfactant is produced by type II alveolar cells and is composed of two major fractions: phospholipids (90%) and surfactant-specific proteins (10%).

What is the most common complication of surfactant administration in a preterm neonate?

How many times can you give surfactant?

Ideally the dose should be given within 1 hr of birth but definitely before 2 hours of age. A repeat dose should be given within 4 – 12 hours if the patient is still intubated and requiring more than 30 to 40% oxygen….Indications.