Does pigmentary mosaicism go away?

Pigmentary mosaicism is a permanent color change in the skin. We are not able to change the genetic material to make the skin color the same.

Is pigmentary mosaicism common?

Most frequently, pigmentary mosaicism appears sporadically, but a family history of the condition was described in 4% of the reported cases. A rare case of two paternal half-brothers with pigmentary mosaicism of the hyperpigmented type was reported [26].

What is the most common extracutaneous involvement associated with pigmentary mosaicism?

Extracutaneous manifestations The most frequently reported extracutaneous anomalies were skeletal deformities, seizures, mental retardation, dysmorphic facial features, and developmental delay.

What is mosaic skin?

What is mosaicism? Mosaicism describes an individual composed of two or more genetically different populations of cells existing side by side within the skin. The two cell lines develop very very early in the life of the embryo. Many genetic skin disorders reflect cutaneous mosaicism.

How are pigmentary demarcation lines treated?

Pigmentary demarcation line in pregnancy may regress spontaneously after delivery and does not require treatment. Facial PDL has a persistent course posing cosmetic concern for the patient and a challenge for dermatologist.

What causes genetic mosaicism?

Mosaicism occurs when a person has two or more genetically different sets of cells in his or her body. If those abnormal cells begin to outnumber the normal cells, it can lead to disease that can be traced from the cellular level to affected tissue, like skin, the brain, or other organs.

What is Hypomelanosis of Ito?

Hypomelanosis of Ito (HMI) is a very rare birth defect that causes unusual patches of light-colored (hypopigmented) skin and may be associated with eye, nervous system, and skeletal problems.

What is an example of mosaicism?

The term “mosaicism” is used to describe the presence of more than one type of cell in a person. For example, a person may have some of the cells in their body with 46 chromosomes, while other cells in their body have 47 chromosomes. An example of mosaicism is mosaic Down syndrome.

Where on the body are pigmentary demarcation lines most commonly seen?

Pigmentary demarcation lines (PDLs) are areas of an abrupt transition from hyper- to hypo-pigmented or normal skin color. They are seen on limbs, face, and sometimes trunk. They are more commonly reported in Japanese and black race and rarely in white races.

What causes pigmentary demarcation lines on legs?

PDL are abrupt transition lines from areas of deeper pigmentation to areas with less pigmentation. The exact cause is unknown, but Type B lines, as seen with our patient, tend to appear during pregnancy on the lower limbs, and regress after delivery.

What is pigmentary mosaicism and how is it characterized?

[…] Pigmentary mosaicism is a term that describes varied patterns of pigmentation in the skin caused by genetic heterogeneity of the skin cells. In a substantial number of cases, pigmentary mosaicism is observed alongside extracutaneous abnormalities typically involving the central nervous system and the musculoskeletal system.

Is segmental dyspigmentation a mosaic disorder?

Mosaicism implies the coexistence of a normal and one or more abnormal components, and opposed to this, a few individuals with segmental dyspigmentation have been shown to be chimeric, i.e. consist of cell lines with different but completely normal genome.

What are the treatment recommendations for pigmentary mosaicism?

Based on the results found in this review, we recommend that patients with pigmentary mosaicism undergo physical examination, highlighting with Wood’s light, and karyotyping from peripheral blood lymphocyte … Pigmentary mosaicism: a review of original literature and recommendations for future handling

What is the pathophysiology of mosaicism?

The term “pigmentary mosaicism” refers to patterned hypo- or hyperpigmentation resulting from a clone of skin cells with altered ability to produce melanin. The three major clinical patterns are streaks and swirls following the Blaschko lines (figure 1), a segmental or “checkerboard” distribution, and a phylloid (leaf-like) arrangement.