Can sulfasalazine cause rashes?

A severe adverse reaction to sulfasalazine has been identified as a type of hypersensitivity syndrome. The reaction, including fever, skin rash, lymphadenopathy, and internal organ involvement, usually occurs 2 to 5 weeks after initiating treatment with sulfasalazine.

Can sulfasalazine cause hives?

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What are the most common side effects of sulfasalazine?

Common side effects — The most common side effects of sulfasalazine are headache, nausea, fever, rash, and reversible infertility in men. Headache is one of the most common complaints, affecting up to one-third of people.

What are the long term effects of taking sulfasalazine?

Dyspepsia, nausea and abdominal discomfort were the most common side-effects, although rashes (3) and macrocytosis (2) also occurred. Eighteen of the 21 patients treated with penicillamine improved during 9 months, although there was some deterioration at 1 year.

Can sulfasalazine cause itchy skin?

Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn.

How do I know if I am allergic to sulfasalazine?

Call your doctor right away if you have difficulty breathing or swallowing, a fast heartbeat, itching, rash, or skin redness, or swelling of the face, throat, or tongue. These may be symptoms of an allergic reaction to this medicine.

Will sulfasalazine side effects go away?

Some side effects of sulfasalazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Can sulfasalazine cause skin problems?

Can you take antihistamines with sulfasalazine?

No interactions were found between sulfasalazine and Zyrtec.

Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:

What are the hypersensitivity reactions to sulfasalazine in rheumatology?

Leroux JL, Ghezail M, Chertok P, Blotman F “Hypersensitivity reactions to sulfasalazine: skin rash, fever, hepatitis and activated lymphocytes.” Clin Exp Rheumatol 10 (1992): 427

How long does it take for sulfasalazine to cause hepatitis?

Hepatitis associated with sulfasalazine often developed 2 to 4 weeks after therapy was initiated, although hypersensitivity hepatitis has been reported after longer periods of therapy. Associated rash usually progressed to desquamation.

What are the signs and symptoms of sulfasalazine-induced systemic lupus erythema (SLE)?

In most cases of sulfasalazine-induced SLE, patients received the drug for greater than 1 year. Patients most commonly developed arthralgias and pleuritic chest pain. Generally, these patients had a positive ANA, anti-DNA antibody titer, and were slow acetylators of sulfonamides.