Can hyperuricemia be asymptomatic?

Can hyperuricemia be asymptomatic?

Asymptomatic hyperuricemia is a term traditionally applied to settings in which the serum urate concentration is elevated but in which neither symptoms nor signs of monosodium urate (MSU) crystal deposition disease, such as gout, or uric acid renal disease, have occurred.

Why is asymptomatic hyperuricemia generally not treated?

Abstract. Treatment of asymptomatic hyperuricemia is not necessary in most patients, unless perhaps they have very high levels of uric acid or are otherwise at risk of complications, such as those with a personal or strong family history of gout, urolithiasis, or uric acid nephropathy.

Should you treat asymptomatic hyperuricemia?

Pharmacologic treatment for asymptomatic hyperuricemia carries some risk, is not considered beneficial or cost-effective, and generally is not recommended. However, these patients can be advised on lifestyle changes such as changes in diet, reduction in alcohol intake, and exercise, which may lower uric acid levels.

How should we manage asymptomatic hyperuricemia?

Medications for comorbidities that elevate urate levels should be discontinued and replaced with medications that have the opposite effect. Therapeutic lifestyle changes, weight loss as appropriate, and sufficient physical activity are useful for improving general health.

What underlying causes contribute to asymptomatic hyperuricemia?

Hyperuricemia can be due to underexcretion or overproduction of uric acid or both; the cause may affect the management. Some researchers believe hyperuricemia is a risk factor for ischemic heart disease, and it has been associated with diabetes mellitus, lipid abnormalities, hypertension, stroke, and preeclampsia.

What is asymptomatic D?

Asymptomatic means there are no symptoms. You are considered asymptomatic if you: Have recovered from an illness or condition and no longer have symptoms. Have an illness or condition (such as early stage high blood pressure or glaucoma) but do not have symptoms of it.

Can hyperuricemia be cured?

It is possible to treat hyperuricemia through dietary changes. Consuming fewer foods and drinks that are high in purine can reduce uric acid in the blood. This reduction helps the kidneys to filter out uric acid more effectively again.

How do you test for hyperuricemia?

A uric acid test can be done as a blood test or a urine test. During a blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial.

What is the role of the kidneys in producing hyperuricemia?

The kidney is an important regulator of circulating uric acid levels, by reabsorbing around 90% of filtered urate, while being responsible for 60–70% of total body uric acid excretion. Defective renal handling of urate is a frequent pathophysiologic factor underpinning hyperuricemia and gout.

What are the two main types of hyperuricemia?

Of these, alcohol consumption is the most important. Causes of hyperuricemia can be classified into three functional types: increased production of uric acid, decreased excretion of uric acid, and mixed type. Causes of increased production include high levels of purine in the diet and increased purine metabolism.

What percentage of Covid cases are asymptomatic?

Based on data from a meta-analysis of 95 studies that included nearly 30,000,000 individuals, the pooled percentage of asymptomatic COVID-19 infections was 0.25% in the tested population and 40.5% among confirmed cases.

What is the relationship between hyperuricemia and CKD?

Because the serum uric acid level increases as the glomerular filtration rate (GFR) decreases, hyperuricemia is associated with chronic kidney disease (CKD). Although hyperuricemia is a risk factor for CKD progression, the causal role of uric acid remains controversial in patients with CKD and asymptomatic hyperuricemia.

Does uric acid play a role in the progression of hyperuricemia?

Although hyperuricemia is a risk factor for CKD progression, the causal role of uric acid remains controversial in patients with CKD and asymptomatic hyperuricemia. This study included 588 patients with stage 3-4 CKD and asymptomatic hyperuricemia.

Does febuxostat improve kidney function in patients with Stage 3 hyperuricemia?

Conclusions: Compared to placebo, febuxostat did not mitigate the decline in kidney function among patients with stage 3 CKD and asymptomatic hyperuricemia. Funding: Funded by Teijin Pharma Limited.

Is asymptomatic hyperuricemia an indication for Urate-lowering therapy?

At present, asymptomatic hyperuricemia is not an indication for urate-lowering therapy, though emerging data may support a potential renoprotective effect.